Seroprevalence of hepatitis e virus in five high-risk populations from the Republic of Moldova: a cross-sectional study
Vol. 6 No. 2 (2025), Research articles
Vol. 6 No. 2 (2025)

Seroprevalence of hepatitis e virus in five high-risk populations from the Republic of Moldova: a cross-sectional study

Research articles
https://doi.org/10.38045/ohrm.2025.2.03
Published June 16, 2025
Octavian SAJIN
National Agency for Public Health
Nina IZIUMOV
National Agency for Public Health
Adela ȚURCANU
SUMP ”Nicolae Testemitanu”
Angela PARASCHIV
SUMP ”Nicolae Testemitanu”
Tiberiu HOLBAN
SUMP ”Nicolae Testemitanu”
Valentina BLAJ
National Agency for Public Health
Volume_6,Issue_2
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Keywords

Hepatitis E virus
Moldova
risk groups
anti-HEV antibodies
seroprevalence

How to Cite

Sajin, O., Iziumov, N., Țurcanu, A., Paraschiv, A., Holban, T. and Blaj, V. (2025) “Seroprevalence of hepatitis e virus in five high-risk populations from the Republic of Moldova: a cross-sectional study”, One Health & Risk Management , 6(2), pp. 33-44. doi: 10.38045/ohrm.2025.2.03.
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Abstract

Introduction. The study assessed the seroprevalence of Hepatitis E virus (HEV) markers in different at-risk groups within the Republic of Moldova. The risk groups included blood donors, hemodialysed patients, medical workers, tuberculosis (TB) patients, and intravenous drug users (IDUs).

Material and methods. A cross-sectional descriptive-epidemiological study was conducted from 2019 to 2023, with participants randomly selected from different risk groups. Blood samples were collected and tested using ELISA for Anti-HEV IgG and IgM markers. Seroprevalence was calculated with 95% confidence intervals, and statistical analyses were conducted using Epi Info 7.2 software.

Results. Among 794 tested blood donors, 9.6% (95% CI: 7.7-11.8) were positive for Anti-HEV IgG, indicating past exposure, and 8.3% (95% CI: 6.3-10.8) for Anti-HEV IgM, suggesting recent infection. Hemodialyzed patients had a significantly higher seroprevalence: 45.8% (95% CI: 34.8–57.1) for Anti-HEV IgG and 21.6% (95% CI: 9.8–38.2) for Anti-HEV IgM. Medical workers exhibited moderate IgG prevalence at 11.8% (95% CI: 9.1-15.0) and substantially higher IgM prevalence at 38.1% (95% CI: 26.1-51.2). TB patients had lower IgG (11.9%, 95% CI: 7.8-17.2) and IgM (7.8%, 95% CI: 3.6-14.3) prevalences. IDUs had a notable IgG prevalence of 20.5% (95% CI: 12.6-30.4) but no detectable IgM.

Conclusions. This study highlights the significant burden of hepatitis E virus infection among at-risk populations in the Republic of Moldova.

https://doi.org/10.38045/ohrm.2025.2.03
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Copyright (c) 2025 Octavian Sajin, Nina Iziumov, Adela Țurcanu, Angela Paraschiv, Tiberiu Holban, Valentina Blaj

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