Exploring the relationship between dietary patterns and the RS2241766 polymorphism of adiponectin gene in coronary artery disease
Volume_6,Issue_2
pdf

Keywords

Gene-Diet Interaction
adiponectin Rs2241766
coronary artery disease
genotype
dietary pattern

How to Cite

Rabiathul Bhashira.R and Gopalakrishnan S., S. (2025) “Exploring the relationship between dietary patterns and the RS2241766 polymorphism of adiponectin gene in coronary artery disease: a gene-diet interaction study”, One Health & Risk Management , 6(2), pp. 6-17. doi: 10.38045/ohrm.2025.2.01.

Abstract

 Introduction. The coronary artery disease remains a major health issue worldwide, especially in low- and middle-income countries where genetic predispositions significantly contribute to its prevalence.

Materials and methods. This study, conducted at Chettinad Hospital and Research Institute, Kelambakkam, India, from January to April 2024, investigates the relationship between dietary patterns, genetic variations in Adiponectin, and coronary artery disease risk. Genetic analysis of the adiponectin (45T/G) polymorphism was performed using the Tetra-primer Amplification Refractory Mutation System Polymerase Chain Reaction method. 

Results. The results revealed notable links between genetic variations, dietary behaviours, and health indicators coronary artery disease patients. Anthropometric and biochemical measurements showed that narrowed coronary arteries were associated with elevated BMI and waist circumference. Lifestyle and sleep patterns also differed significantly between the groups. Among coronary artery disease participants, 64% followed non-vegetarian diets, with higher consumption of red meat and fast food, negatively impacting lipid profiles. The rs2241766 GG genotype of the adiponectin gene was significantly associated with these dietary habits (p<0.01) and obesity (OR=5.1429, p=0.0084). Similarly, the GT genotype demonstrated a strong correlation with obesity (OR=22.15, p < 0.050). 

Conclusions. This study highlights the intricate connections between genetic predispositions, dietary choices, and coronary artery disease risk. The rs2241766 GG genotype emerged as a strong predictor of coronary artery disease susceptibility compared to the rs2231142 TT genotype, emphasizing the complex interplay of diet, genetics and obesity in coronary artery disease development.

https://doi.org/10.38045/ohrm.2025.2.01
pdf

|Views: 172| |pdf Downloads: 91|


pdf
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2025 Rabiathul Bhashira.R, Santhini Gopalakrishnan S.

Downloads

Download data is not yet available.

ANNOUNCEMENT

Starting from July 1, 2025, the article processing fee will be 20 EUR (or the equivalent in MDL at the official exchange rate of the National Bank of Moldova). The publication fee for an accepted article will be 150 EUR (or the equivalent in MDL).

Details here:

Processing Fee
A processing fee of 20 EUR (or the equivalent in MDL) will be charged for articles accepted for scientific review by the editorial committee of the One Health and Risk Management journal.
Note: This fee will only be charged if your article has been technically reviewed and accepted.

Publication Fee
Starting from 01.07.2025, a fee of 150 EUR (or the equivalent in MDL) will be charged for articles accepted for publication.
Additionally, authors will bear the cost of English language editing/translation services if the manuscript requires intervention. The fee is 5 EUR (or the equivalent in MDL) per page edited/translated.
The total cost for English editing/translation services will be communicated by the Editorial Board after the manuscript is accepted for publication.

Payment Details:
Payments should be made in MDL to the bank account opened in the name of the Biosafety and Biosecurity Association of the Republic of Moldova.
The invoice will be issued by the end of the month in which the payment was made.

Organization: Biosafety and Biosecurity Association of the Republic of Moldova
Address: 5C A. Cozmescu Street
Fiscal Code: 1017620004120
Bank Code (SWIFT): AGRNMD2X451
IBAN: MD34AG000000022513622370