Emneord (Nøkkelord)
One Health
human health
farm animals
Hvordan referere
Sammendrag
Introduction Cystic echinococcosis (CE) is a zoonotic parasitic disease that affects both human and animal health, causing considerable socioeconomic losses. This study aimed to assess the epidemiological trends and distribution of CE in humans and livestock in the Republic of Moldova from a One Health perspective.
Materials and Methods A retrospective descriptive study was conducted using data from the National Agency for Public Health (NAPH) and the National Agency for Food Safety (NAFS). Human CE surgical cases reported during 2011–2024 (n=995) and CE cases detected in slaughtered animals during 2014–2023 (n=95,898) were analyzed. Indicators included incidence, demographic and territorial distribution, and cyst localization.
Results Human CE incidence decreased from 2.2 to 1.87 cases per 100,000 population during 2016–2024, while animal prevalence declined from 24.5% in 2014 to 4.7% in 2024. The highest incidence rates were recorded in Ceadîr-Lunga (12.6), Drochia (6.2), Taraclia (6.1), Florești and Basarabeasca (6.0), and Leova (5.7) per 100,000 population, exceeding the national average (1.9). Adults aged 31-60 years accounted for 59.0% of human cases. Sheep had the highest prevalence among livestock species (7.3%).
Conclusions Although declining trends were observed in both humans and animals, CE remains a significant public health and veterinary concern in the Republic of Moldova. Strengthened surveillance and intersectoral collaboration within the One Health framework are essential to reduce transmission and improve disease control.
Referanser
1. Neghina R, Neghina AM, Marincu I, Iacobiciu I. Epidemiology and epizootology of cystic echinococcosis in Romania 1862–2007. Foodborne Pathog Dis. 2010;7(6):613-618. doi:org/10.1089/fpd.2009.0489
2. Dumitriu A. Răspândirea helmintozelor la Canis familiaris în unele gospodării particulare de ovine. Medicină veterinară. 2013: 182-184. Accessed May 13, 2025. https://ibn.idsi.md/sites/default/files/imag_file/182-184_5.pdf
3. Dumitriu A, Paterău A. Poliparazitismul la câinii și pisicile din orașul Chișinău. Medicină veterinară. 2013: 207-208. Accessed May 13, 2025. https://ibn.idsi.md/sites/default/files/imag_file/207-208_3.pdf
4. Deplazes P, Eckert J. Veterinary aspects of alveolar echinococcosis—a zoonosis of public health significance. Vet Parasitol. 2001; 98:65-87. https://doi.org/10.1016/S0304-4017(01)00424-1
5. World Health Organization; World Organisation for Animal Health. Manual on Echinococcosis in Humans and Animals: A Public Health Problem of Global Concern. WHO; 2001. Accessed May 13, 2025. https://www.who.int/publications/i/item/929044522X.
6. Ghai RR, Wallace RM, Kile JC, Shoemaker TR, Vieira AR, Negron ME, et al. A generalizable One Health framework for the control of zoonotic diseases. Sci Rep. 2022;12(1):8588 doi:10.1038/s41598-022-12619-1
7. Hajjafari A, Rostami-Nejad M, Harandi MF, et al. Advances in Detecting Cystic Echinococcosis in Humans and Animals. Vet Sci. 2024;11(6):227. https://doi.org/10.3390/vetsci11060227
8. Food and Agriculture Organization of the United Nations (FAO), World Organisation for Animal Health (WOAH), World Health Organization (WHO), United Nations Environment Programme (UNEP). One Health Joint Plan of Action (2022–2026). Geneva: WHO; 2022.
9. Sharan M, Vijay D, Yadav JP, Bedi JS, Dhaka P. Surveillance and response strategies for zoonotic diseases: a comprehensive review. Sci One Health. 2023;2:100050. doi:org/10.1016/j.soh.2023.100050
10. Michael E, Madon S. Socio-ecological dynamics and challenges to the governance of Neglected Tropical Disease control. Infect Dis Poverty. 2017;6(1):35. doi:10.1186/s40249-016-0235-5
11. Nocerino M, Alvarez Rojas CA, Casulli A, et al. Epidemiological update of cystic echinococcosis in livestock and assessment of practices related to its control in the Mediterranean area. Acta Tropica 2024; 255:107240. ⟨10.1016/j.actatropica.2024.107240⟩.
12. Dumitriu A. Bolile parazitare zoonotice - un risc ascuns pentru sănătatea publică. One Health and Risk Management. 2023;2:63. Accessed May 13, 2025. https://journal.ohrm.bba.md/index.php/journal-ohrm-bba-md/article/view/643/566
13. Casulli A, et al. Unveiling the incidences and trends of the neglected zoonosis cystic echinococcosis in Europe: a systematic review from the MEME project. The Lancet Infectious Diseases, 2023;23:e95-e107, doi:10.1016/S1473-3099(22)00638-7.
14. European Centre for Disease Prevention and Control. Echinococcosis. In: ECDC. Annual Epidemiological Report for 2022. Stockholm: ECDC; 2024. Accessed May 13, 2025. https://www.ecdc.europa.eu/en/publications-data/echinococcosis-annual-epidemiological-report-2022
15. European Centre for Disease Prevention and Control. Echinococcosis. In: Annual epidemiological report for 2021. Stockholm: ECDC; 2024. Accessed May 13, 2025. https://www.ecdc.europa.eu/en/publications-data/echinococcosis-annual-epidemiological-report-2021
16. European Centre for Disease Prevention and Control. The European Union one health 2023 zoonoses report. Stockholm: ECDC; 2024. Accessed May 12, 2025. https://www.ecdc.europa.eu/en/publications-data/european-union-one-health-2023-zoonoses-report
17. Dumitriu A, Petrova V. Povara echinococozei chistice în Republica Moldova, 2014-2023. In: Lucrări științifice: Medicină Veterinară. Materialele Simpozionului Științific Internațional „50 ani de învățământ superior medical veterinar din Republica Moldova”. Chișinău; 2025:101-104. doi:10.52326/ismv2024.22
18. Sîrbu A, Spătaru D. Epidemiology and public health challenges of echinococcosis in the Republic of Moldova. Acta Marisiensis Ser Med. 2025;71(2):121-125.doi:10.2478/amma-2025-0016
19. Agenția Națională pentru Sănătate Publică. Supravegherea de stat a sănătăţii publice în Republica Moldova: raport național 2024. Chișinău: ANSP; 2024. Accessed May 13, 2025. https://ansp.md/wp-content/uploads/2025/05/RAPORT-ANUAL-ANSP-2024.pdf
20. Awosanya EJ, et al. Prevalence of Echinococcus granulosus sensu lato in definitive hosts. Vet Sci. 2021;8(6):101.doi:10.3390/vetsci8060101
21. Center for Food Security & Public Health. Echinococcosis (hydatidosis, hydatid disease). Ames, IA: CFSPH; 2025. Accessed May 13, 2025. https://www.cfsph.iastate.edu/Factsheets/pdfs/echinococcosis.pdf
22. Chihai O, Umhang G, Erhan D, et al. Slaughterhouse survey of cystic echinococcosis in cattle and sheep from the Republic of Moldova. J Helminthol. 2016; 90(3):279-283. doi:10.1017/S0022149X15000103
23. Wang Y, Zhang R, Zhang D, Liang Y, Xu C, Zhang C. Global burden of cystic echinococcosis: a 32-year analysis of 204 countries with 2036 projections. BMC Public Health. 2025; 25(1):3213. doi: 10.1186/s12889-025-24502-5.
24. Ahmadi NA, Hamidi M. A retrospective analysis of human cystic echinococcosis in Hamedan province, an endemic region of Iran. Ann Trop Med Parasitol. 2008;102(7):603-609. doi:10.1179/136485908x337517
25. Moreno J, Téllez CJ, Pardo FJ. Casos de hidatidosis en el Departamento de Salud 2 de la Comunidad Valenciana [Hydatid disease in the Department of Health #2 of the the Valencian Community (Spain)]. Rev Esp Quimioter. 2009;22(2):62-67. Accessed May 12, 2025. http://seq.es/seq/0214-3429/22/2/moreno.pdf
26. Varbobitis IC, et al. Decreasing trends of ultrasonographic prevalence of cystic echinococcosis in a rural Greek area. Eur J Clin Microbiol Infect Dis. 2010;29(3):307-309. doi:10.1007/s10096-009-0858-6
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Opphavsrett 2026 Antonina DUMITRIU, Diana SPĂTARU, Oxana CONSTANTINOVA