@article{PELTEC_ALNABGHALIE_2021, title={Endothelial dysfunction in nonalcoholic fatty liver disease }, volume={3}, url={https://journal.ohrm.bba.md/index.php/journal-ohrm-bba-md/article/view/281}, DOI={10.38045/ohrm.2022.1.01}, abstractNote={<p><strong><em>Introduction.</em></strong><em> The prevalence of nonalcoholic fatty liver disease (NAFLD) in western countries is increasing rapidly and is considered as component of metabolic syndrome. Endothelial dysfunction is a pathophysiological problem of cardiovascular disease. NAFLD, as a component of metabolic syndrome, is associated with endothelial dysfunction. </em></p> <p><strong><em>Material and methods.</em></strong> <em>PubMed database</em><em> was used in order to review and select articles according to the keywords. A total of 216 articles matching search criteria were found between 2000-2021. </em></p> <p><strong><em>Results. </em></strong><em>The present study has been underlined the role of pathophysiological mechanisms of endothelial dysfunction in nonalcoholic fatty liver disease, which involves oxidative stress, inflammation and insulin resistance. The main factor</em> in&nbsp;<em>the occurrence</em> of&nbsp;<em>endothelial dysfunction is related to nitric oxide (NO) biosynthesis. The markers associated with regulation of nitric oxide biosynthesis, such as asymmetric dimethylarginine, free fatty acid, lectin-like oxidized low-density lipoprotein (LDL) receptor-1 and pentraxin-3, are potential targets in the assessment of endothelial dysfunction. </em></p> <p><strong><em>Conclusions.</em></strong><em> Insulin resistance, inflammation and oxidative stress have been involved in the reduction of NO biosynthesis that influences the occurrence of endothelial dysfunction. Markers, such as lectin-like oxidized LDL receptor-1 and pentraxin-3, have been considered as potential targets in the assessment of endothelial dysfunctions in NAFLD. </em></p&gt;}, number={1}, journal={One Health & Risk Management }, author={PELTEC, Angela and ALNABGHALIE, Murad}, year={2021}, month={Nov.}, pages={4-10} }